Detecting duplicate patient participation in clinical trials is a major challenge because repeated patients can undermine the credibility and accuracy of the trial's findings and result in significant health and financial risks. Developing accurate automated speaker verification (ASV) models is crucial to verify the identity of enrolled individuals and remove duplicates, but the size and quality of data influence ASV performance. However, there has been limited investigation into the factors that can affect ASV capabilities in clinical environments. In this paper, we bridge the gap by conducting analysis of how participant demographic characteristics, audio quality criteria, and severity level of Alzheimer's disease (AD) impact the performance of ASV utilizing a dataset of speech recordings from 659 participants with varying levels of AD, obtained through multiple speech tasks. Our results indicate that ASV performance: 1) is slightly better on male speakers than on female speakers; 2) degrades for individuals who are above 70 years old; 3) is comparatively better for non-native English speakers than for native English speakers; 4) is negatively affected by clinician interference, noisy background, and unclear participant speech; 5) tends to decrease with an increase in the severity level of AD. Our study finds that voice biometrics raise fairness concerns as certain subgroups exhibit different ASV performances owing to their inherent voice characteristics. Moreover, the performance of ASV is influenced by the quality of speech recordings, which underscores the importance of improving the data collection settings in clinical trials.

Multi-taper estimators provide low-variance power spectrum estimates that can be used in place of the windowed discrete Fourier transform (DFT) to extract speech features such as mel-frequency cepstral coefficients (MFCCs). Even if past work has reported promising automatic speaker verification (ASV) results with Gaussian mixture model-based classifiers, the performance of multi-taper MFCCs with deep ASV systems remains an open question. Instead of a static-taper design, we propose to optimize the multi-taper estimator jointly with a deep neural network trained for ASV tasks. With a maximum improvement on the SITW corpus of 25.8% in terms of equal error rate over the static-taper, our method helps preserve a balanced level of leakage and variance, providing more robustness.